https://journals.goodwoodpub.com/index.php/jimi <p style="text-align: justify;">Jurnal Ilmu Medis Indonesia / Indonesian Journal of Medical Sciences (JIMI) is a peer-reviewed scholarly journal that publishes articles in the field of medical sciences in Indonesia. JIMI welcomes researchers, academicians, as well as practitioners to submit well-written manuscripts discussing contempory and interesting medical issues aimed at mediating the development of Indonesian medical sciences through a quality scientific publication.</p> Penerbit Goodwood en-US Jurnal Ilmu Medis Indonesia 2807-1697 <p>Authors who publish with this journal agree to the following terms:</p> <ol> <li class="show">Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a&nbsp;<a href="http://creativecommons.org/licenses/by-sa/4.0/" target="_blank" rel="noopener">Creative Commons Attribution License (CC BY-SA 4.0)</a>&nbsp;that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.</li> <li class="show">Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.</li> <li class="show">Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.</li> </ol> https://journals.goodwoodpub.com/index.php/jimi/article/view/5711 <p><strong>Purpose: </strong>This review evaluates the potential role of kombucha in Colorectal Cancer (CRC) prevention and adjunctive therapy through the microbiota–metabolite–host axis, emphasizing bioactive compounds, fermentation metabolites, gut microbiota, oxidative-inflammatory pathways, immune responses, and carcinogenesis.<br /><strong>Methods: </strong>A review of studies published between 2015 and 2025 was conducted using PubMed, ScienceDirect, and Google Scholar. Experimental, preclinical, clinical, and review evidence on kombucha, fermented tea, microbiota, microbial metabolites, probiotics, prebiotics, oxidative stress, inflammation, CRC, and anticancer mechanisms was synthesized.<br /><strong>Results: </strong><span lang="ZH-CN">Kombucha may modulate the gut microbiota, metabolism, oxidative stress, inflammation, immunity, proliferation, and apoptosis through its bioactive compounds. However, evidence for the prevention or treatment of CRC remains largely preclinical.<br /></span><strong>Conclusions: </strong>Kombucha may provide a mechanistic basis for investigating its use as a dietary adjunct for CRC prevention and supportive care; however, its therapeutic efficacy requires confirmation in human studies.<br /><strong>Limitations: </strong>Evidence is limited by heterogeneous fermentation conditions, composition, microbial communities, metabolite profiles, insufficient strain-specific characterization, and scarce standardized human interventions.<br /><strong>Contributions: </strong>This review integrates kombucha evidence within a microbiota–metabolite–host framework, connecting fermented tea bioactives, microbial ecology, metabolite signaling, intestinal homeostasis, and CRC pathways, while identifying priorities for metabolomic, microbiome, mechanistic, and clinical research.</p> Khairun Nisa Berawi Yasmin Nafisah Putri Michelle Adiva Ade Yonata Ihsanti Dwi Rahayu Copyright (c) 2026 Khairun Nisa Berawi, Yasmin Nafisah Putri, Michelle Adiva, Ade Yonata, Ihsanti Dwi Rahayu https://creativecommons.org/licenses/by-sa/4.0 2026-09-08 2026-09-08 6 1 1 18 10.35912/jimi.v6.n1.p1-18.2026 https://journals.goodwoodpub.com/index.php/jimi/article/view/6999 <p><strong>Purpose</strong><strong>:</strong> This study aimed to determine the relationship between chemical exposure (paint, thinner, and solvent) and health complaints among painting workers in confined spaces at PT Pahala Harapan Lestari in 2026.<br /><strong>Research Methodology</strong>: This study employed a quantitative analytical approach with a cross-sectional design. The study involved 30 painting workers selected using total sampling technique. Primary data were collected through structured questionnaires and interviews. Data were analyzed using univariate and bivariate analyses, followed by the chi-square test using IBM SPSS statistics.<br /><strong>Results</strong>: The findings indicated a significant relationship between paint exposure and health complaints among painting workers in confined spaces (p=0.006). However, exposure to thinner (p=0.483) and solvent (p=0.224) was not significantly associated with health complaints. The most common complaints after painting activities in confined spaces were dizziness, eye irritation, shortness of breath, nausea, and fatigue.<br /><strong>Conclusions</strong>: Paint exposure was significantly associated with health complaints, whereas thinner and solvent exposure showed no significant relationship. These findings highlight the importance of implementing Occupational Safety and Health (OSH) measures, including the proper use of personal protective equipment and adequate workplace ventilation, to reduce chemical exposure.<br /><strong>Limitations</strong>: This study was conducted in a single company with a relatively small sample size; therefore, the findings cannot be generalized to the entire shipbuilding industry.<br /><strong>Contributions</strong>: This study provides scientific evidence regarding the relationship between chemical exposure and health complaints among confined-space painting workers and may support the improvement of occupational safety and health programs in the shipbuilding industry</p> Septy Anggraini Taufik Kurrohman Murniani Murniani Rendita Dwibarto Copyright (c) 2026 Septy Anggraini, Taufik Kurrohman, Murniani Murniani, Rendita Dwibarto https://creativecommons.org/licenses/by-sa/4.0 2026-09-08 2026-09-08 6 1 19 28 10.35912/jimi.v6.n1.p19-28.2026